Scientific Research and Clinical Studies

The Osato Research Institute (ORI) is a non-profit organization founded in 2004 and based in Gifu, Japan. ORI conducts and coordinates scientific programs and clinical studies that focus on our natural defence systems, healthy living, healthy aging, and Osato ‘fermented papaya preparation’ or FPP®.

World-renowned scientists have been studying FPP® properties and as members of our scientific board, they have contributed to scientifically prove the effects of FPP® on the immune system, the anti oxidative system, and the production of cellular energy.

Our members come from very different fields and many different countries. They communicate their research findings on FPP® at international academic conferences, at ORI scientific committee meetings, and in scientific journals.

We are presenting below the main research and studies that have been done on FPP® by ORI.

Publications and references available on Medline (PubMed) and at 

First discoveries

FPP® has been studied in several published clinical studies, which can be found below ⬇️


Immuno-stimulating properties:

  • Actions of FPP® on the cells of the immune system | Pr. Lester Packer | ISBN 2-7046-1675-2
  • Nitric oxide synthesis and TNF-secretion in RAW 264.7 macrophages | G. Rimbach & co | PMID: 12659174

Anti-oxidative properties:

  • Nutraceutical Supplementation: Effect of a Fermented Papaya Preparation on Redox Status and DNA Damage in Healthy Elderly Individuals and Relationship with GSTM1 Genotype. A Randomized, Placebo-Controlled, Cross-Over Study. | F. Marotta & Co | PMID: 16804018
  • Advantages of Fermented Papaya on our health: Beneficial effects on oxidative stress and immunity: oxidative stress and chronic diseases. | Pr. Luc Montagnier | ISBN 2-7046-1675-2

On cellular energy production:

  • Does Oral Supplementation of a Fermented Papaya Preparation Correct Respiratory Burst Function of Innate Immune Cells in Type 2 Diabetes Mellitus Patients. Ryan Dickerson & co | PMID:25268638

Research on specific uses

More clinical studies have been made on FPP ⬇️

  • Respiratory tract protection: can help fight infections by reducing the damaging effect of oxidative stress, thus boosting the natural defence of the respiratory mucous membrane.
    Reference: Is there a potential application of a fermented nutraceutical in acute respiratory illnesses? | F. MAROTTA & Co | PMID: 22824755 
  • Protection against oxidative stress in Alzheimer’s disease and Parkinson’s disease: can help protect against oxidative stress-related damages caused by these diseases.
    Reference: Oxidative Stress in Patients with Alzheimer’s Disease: Effect of Extracts of Fermented Papaya Powder. | M. BARBAGALLO & Co | Hindawi Publishing Corporation, Mediators of Inflammation, Article ID 624801
  • Protection against cardiovascular diseases: can help maintain good cardiovascular health by protecting the body against the dysfunction of the inner lining of the blood vessels.
    Reference: Cardioprotective effect of a bio fermented nutraceutical on endothelial function in healthy middle-aged subjects. | F. MAROTTA & Co | PMID: 22533427
  • Skin aging: improvement of hydration, elasticity and uniformity of the skin; protection against skin aging.
    Reference: Testing a quality-controlled fermented nutraceutical on skin aging markers: an antioxidant controlled, double-blind study | N. ZERBINATI & Co | PMID: 26998011
  • Protection against chronic wound infection in type II diabetic patients: corrects deficit in neutrophil respiratory burst capacity of T2D patients and consequently strengthens the ability of the body to fight infections. It also increases angiogenesis locally, thus promoting the healing process.
    References: Does oral supplementation of a fermented papaya preparation correct respiratory burst function of innate immune cells in type 2 diabetes mellitus patients? | R. Dickerson & Co | PMID: 25268638 - May Dietary Supplementation Augment Respiratory Burst in Wound-Site Inflammatory Cells? | A. DAS & Co | PMID: 28810801
  • Protection against the electromagnetic field intolerance syndrome (EMFIS): diminution of number and severity of clinical symptoms (headache, fatigue, tachycardia episodes, insomnia, attention deficit).
    References: Phase I-II study testing the therapeutic effect and stimulating properties of antioxidant defences to patients suffering of Electromagnetic Fields Intolerance Syndrome. | D. BELPOMME & Co | Functional Foods in Health and Disease 2018; 8(2): 122-144 - US Patent No.US10993980B2 – “Method for Treating Electrohypersensitivity with FPP®”